Vol. 6, Issue 1, Part A (2024)

Background: Empty follicle syndrome (EFS) is a condition in which no oocytes are retrieved after adequate ovarian response to stimulation and meticulous follicular aspiration. The etiology remains enigmatic and its occurrence is a frustrating complication of IVF, leading to cycle cancellation.
Case Report: A case of 32 years female presented with her 35 years old husband to our infertility clinic, married for 7 years and unable to conceive since 4 years. Before presenting to our clinic she has underwent ovulation induction and four cycles of IUI. After taking complete history IVF was advised as the next line of management. Ovarian stimulation with recombinant FSH and HMG with two different stimulation protocol was given. After adequate follicular development (> 2 follicles with > 18mm mean diameter) trigger was given and ovum pick up was done after 35 hours. During both ovum retrieval, no oocytes were recovered from both ovaries.
Conclusion: EFS is a rare complication of IVF. It may cause substantial stress and anxiety for both patient and physician. It is therefore of importance to understand EFS and help counsel the couple.