Abstract:
Objective: To compare the effectiveness of intraumbilical oxytocin and placental cord drainage in the management of third stage of labor.
Design: A prospective randomized clinical trial.
Study started: 1 September 2017.
Study completed: 30 January 2018.
Setting: At Ain-Shams University Maternity Hospital.
Subjects: One hundred and fifty pregnant women between 18-35 years of age with normal pregnancy and a singleton fetus at a gestational age of 37 - 42 weeks in a cephalic presentation with neonatal birth weight of 2500 to 4500 grams recruited from the delivery ward of our hospital.
Methods: The 150 study participants were randomly allocated into three groups either 20 units of oxytocin injected in the umbilical vein after clamping (Group A, n = 50), placental cord drainage (Group B, n = 50) or no intervention (Group C, n = 50).
Main outcome measure: Duration of the third stage of labor.
Secondary outcome measure: Retained placenta, need for manual removal of placenta and the drop in Hemoglobin level
postpartum.
Results: there was a significant statistical difference between all groups regarding the duration of the third stage of labour (p
>0.05). With the duration was significantly shorter in the study groups A&B than the control group C, with significantly shorter duration in group B compared to Group A (P1 is 0.001
> 0.05). There was statistical difference between all groups regarding Hemoglobin reduction (p
>0.05).With hemoglobin level significantly reduced in the control group C than the study groups A&B (P2 is 0.016
>0.05 and P3 is 0.0001
>0.05) with significantly higher reduction in group A than Group B (P1 is 0.001
>0.05). As regard Retained placenta and the need for manual removal of placenta there was non-significant increase in the control group C (2 cases) which wasn’t statistically significant (p
<0.05)
while there were no cases in study groups A&B.
Conclusion: The present study demonstrated that the use of intraumbilical injection of oxytocin and placental cord drainage significantly reduced the duration of the third stage in addition a significant decrease in the hemoglobin and hematocrit drop postpartum, however there were non-significant reduction of Retained placenta and the need for manual removal of placenta, Larger studies are necessary to confirm these findings.
